Wort, Hypericum perforatum, generally contains 30-45% total hyperforin content, an antibacterial and anti-inflammatory molecule. Use
of St. John's Wort dates back to ancient Greece where it was used to treat "nervous disorders." Modern research has indicated that St. John's Wort may be used for mild to moderate
depression although I have not found studies indicating that severe depression clients have been studied with St. John's Wort.
It works by
providing the body with natural SSRIs (Serotonin Reuptake Inhibitors). Studies
at the Mayo clinic show that it may be as effective as TCAs - tricyclic antidepressants. Because the body has evolved along side plants for thousands of years, our bodies more effectively
metabolize plants occurring in nature.
Wort doesn't have the side effects like loss of sex drive that other drugs which are considered equally as effective such as fluoxetine (Prozac), citalopram (Celexa), and sertraline
(Zoloft) according to the studies done at the University of Maryland which can be found here.
Quote from the University of Maryland study cited above:
"St. John's wort has also shown promise in treating the following conditions, a few of which are related to depression.